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Oxidación especial en los neutrófilos en pacientes de Behçet
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Según pone en el encabezamiento del artículo, se da un tipo de oxidación especial en el plasma y los neutrófilos aislados en un paciente con Behçet respecto a la actividad en una persona sana.

Os copio el resumen del artículo, puesto que para verlo entero hay que pagar.

Saludos.


Oxidases and oxygenases in regulation of neutrophil redox pathways in Behçet’s disease patients

Posted online on June 24, 2011. (doi:10.3109/14756366.2011.572281)
HTML PDF (630 KB) PDF Plus (631 KB) ReprintsPermissionsMeltem A. Melikoglu1, Cahit Kacar1, Aysegul Cort2, Gultekin Yucel2, Mutay Aslan2
1Department of Physical Medicine-Rheumatology, Faculty of Medicine, Akdeniz University, Antalya, Turkey
2Department of Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey
Address for Correspondence: Dr. Mutay Aslan MD., Ph.D, Department of Biochemistry, Akdeniz University Faculty of Medicine, 07070, Antalya, Turkey. Tel.: 90–242-2496891; Fax: 90–242-2274482. E-mail: mutayaslan@akdeniz.edu.tr



This study aimed to determine plasma and neutrophil oxidase activities that may contribute to vascular inflammation in Behçet’s disease (BD) patients. Cyclooxygenase (COX), NADPH oxidase and myeloperoxidase (MPO) activity was determined in neutrophils isolated from BD patients and healthy controls. Functional assay of NADPH oxidase was significantly increased in BD patients, both at basal conditions and in response to fMLP stimulation. There was a significant increase in plasma MPO activity in the disease group as compared to controls. Total COX activity was significantly increased in BD neutrophils. The increase in total COX activity was accompanied with enhanced activity of COX-2, differentiated by using the COX-1 isoform-specific inhibitor SC-560. Neutrophil nitrate/nitrite levels showed no significant difference in BD; however, plasma nitrate/nitrite contents in BD patients were significantly greater compared to controls. In conclusion, increased plasma MPO, neutrophil NADPH and COX activities may contribute to intravascular inflammation documented in BD patients.

Keywords
Behçet’s disease, neutrophil, NADPH oxidase, myeloperoxidase, cyclooxygenas



Fuente:INFORMAHEALTHCARE.COM
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